An "impediment" is an obstruction or hindrance.
"Egregious" describes something shocking or appalling.
"Prosaic" refers to something dull or unoriginal.
To "bedevil" someone means to cause them trouble or torment.
"Ineffable" describes something too great to be expressed in words
"Abnegation" means outright rejection or renunciation.
"Primordial" indicates something existing from the beginning of time.