Human breast milk is complex than other mammals

Washington D.C.: A study says that milk from a human mother contains more than 200 different sugar molecules, way above the average 30-50 found in any other mammals.

It is still a scientific puzzle that the role of each of these sugar molecules and their composition changes during breast feeding.

Breast milk is often an infant's first meal, but many of the sugar molecules in the milk are not meant to feed the baby. Infants are born sterile of any bacteria in their guts, but within a few days they have millions, and after a week there are billions.

The sugars that come from mother's milk are usually the first compounds that these bacteria have to chew on, a free lunch that is intended to culture specific bacterial species.

Human breast milk also helps lay the foundation for the new baby's immune system. After birth, milk is rich in antibodies and molecules that slow the growth of harmful bacteria and coordinate white blood cell activity.

After one month, when the infant begins developing an adaptive immune system of his or her own, the composition of breast milk transitions so that levels of maternal antibodies drop by more than 90 percent.

There is also a sharp decrease in the diversity of breast milk sugars, indicating less selection for bacterial species. Instead, mature human breast milk has an increased number of fat and other nutrients that support infant growth.

Despite the many functions of breast milk, children can grow up healthy with limited supplies or without ever being exposed; raising controversial questions about what is normal when it comes to breastfeeding. Breast milk clearly reduces infant mortality and significantly decreases a newborn's risk for gut and airway infections, but there's little support for longer-term benefits.

What researchers can do is continue to work on understanding the role of all of the different molecules in breast milk, something that has become much easier with advances in gene sequencing technologies.

The next few years are likely to yield new understanding of the hormones within human breast milk and the exact role of the bacterial populations that it cultures in the infant gut.

This study has been published in Trends in Biochemical Sciences.